HG-9-91-01

Name: HG-9-91-01
Brand: Tocris Bioscience
SKU: 8985

Tocris Bioscience, part of Bio-Techne | Catalog # 8985

COA / SDS

Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.

Key Product Details

Description:	Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.
Alternative Names:	SIK inhibitor 1
Chemical Name:	1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	567.68

View Full Technical Details for HG-9-91-01

Technical Data
Citations

Biological Activity for HG-9-91-01

HG-9-91-01 (SIK1 inhibitor) is a potent pan-salt inducible kinases (pan-SIKs) inhibitor (IC₅₀ values are 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3 respectively). HG-9-91-01 inhibits latrunculin B (Lat-B)-induced endocrine progenitors (EP) differentiation via nuclear YAP1 accumulation in vitro. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in vitro. HG-9-91-01 increases β-cell proliferation in vitro and in vivo (mouse, zebrafish).

Technical Data for HG-9-91-01

M. Wt	567.68
Formula	C₃₂H₃₇N₇O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1456858-58-4
PubChem ID	78357808
InChi Key	UYUHRKLITDJEHB-UHFFFAOYSA-N
Smiles	O=C(N(C1=CC=C(C=C1OC)OC)C2=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=N2)NC5=C(C)C=CC=C5C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HG-9-91-01

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5.68	10
	DMSO	56.77	100

Preparing Stock Solutions for HG-9-91-01

The following data is based on the product molecular weight 567.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.81 mL	17.62 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for HG-9-91-01

References are publications that support the biological activity of the product.

Tian Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage. Stem Cell Rep. 2025 PMID: 40054471
Charbord In vivo screen identifies a SIK inhibitor that induces beta cell proliferation through a transient UPR. Nat.Metab. 2021 PMID: 34031592
Clark Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 23033494