Halofuginone hydrobromide

Name: Halofuginone hydrobromide
Brand: Tocris Bioscience
SKU: 1993

Tocris Bioscience, part of Bio-Techne | Catalog # 1993

Citations (123)

COA / SDS

High affinity competitive prolyl-tRNA synthetase inhibitor

Key Product Details

Description:	High affinity competitive prolyl-tRNA synthetase inhibitor
Chemical Name:	(2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	495.59

View Full Technical Details for Halofuginone hydrobromide

Technical Data
Citations

Biological Activity for Halofuginone hydrobromide

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (K_i = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Technical Data for Halofuginone hydrobromide

M. Wt	495.59
Formula	C₁₆H₁₇BrClN₃O₃.HBr
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	64924-67-0
PubChem ID	400771
InChi Key	SJUWEPZBTXEUMU-LDXVYITESA-N
Smiles	BrC1=CC2=C(C(N(CC(C[C@@H]3[C@H](O)CCCN3)=O)C=N2)=O)C=C1Cl.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Halofuginone hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.56	100

Preparing Stock Solutions for Halofuginone hydrobromide

The following data is based on the product molecular weight 495.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for Halofuginone hydrobromide

References are publications that support the biological activity of the product.

Elkin Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin.Cancer.Res. 1999 PMID: 10473075
Keller Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 PMID: 22327401
Anderson Analysis of the anti-coccidial drug, halofunginone, in chicken feed using gas-liquid chromatography and high-performance liquid chromatography. J.Chromatogr. 1979 PMID: 570196