HA 1100 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2415

Cell-permeable, selective Rho-kinase inhibitor
Discontinued Product
2415 has been discontinued. View all Rho-kinase Inhibitors products.

Key Product Details

Description

Cell-permeable, selective Rho-kinase inhibitor

Alternative Names

Hydroxyfasudil

View all Rho-kinase Inhibitors »

Product Description

HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Product Specifications

Molecular Weight

343.83

Formula

C14H17N3O3S.HCl

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

CAS Number

155558-32-0

PubChem ID

11371328

InChI Key

XWWFOUVDVJGNNG-UHFFFAOYSA-N

SMILES

Cl.OC1=NC=CC2=C(C=CC=C12)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 6.88 20

Preparing Stock Solutions for HA 1100 hydrochloride

The following data is based on the product molecular weight 343.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.54 mL 72.71 mL 145.42 mL
1 mM 2.91 mL 14.54 mL 29.08 mL
2 mM 1.45 mL 7.27 mL 14.54 mL
10 mM 0.29 mL 1.45 mL 2.91 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for HA 1100 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HA 1100 hydrochloride

For research use only

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