HA 1100 hydrochloride

Name: HA 1100 hydrochloride
Brand: Tocris Bioscience
SKU: 2415

Tocris Bioscience, part of Bio-Techne | Catalog # 2415

Citations (10)

COA / SDS

Cell-permeable, selective Rho-kinase inhibitor

Discontinued Product

2415 has been discontinued. View all Rho-kinase Inhibitors products.

Key Product Details

Description:	Cell-permeable, selective Rho-kinase inhibitor
Alternative Names:	Hydroxyfasudil
Chemical Name:	1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	343.83

View Full Technical Details for HA 1100 hydrochloride

Technical Data
Citations

Biological Activity for HA 1100 hydrochloride

HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Technical Data for HA 1100 hydrochloride

M. Wt	343.83
Formula	C₁₄H₁₇N₃O₃S.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	155558-32-0
PubChem ID	11371328
InChi Key	XWWFOUVDVJGNNG-UHFFFAOYSA-N
Smiles	Cl.OC1=NC=CC2=C(C=CC=C12)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for HA 1100 hydrochloride

References are publications that support the biological activity of the product.

Shimokawa Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 1999 PMID: 10615430
Utsunomiya Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 2001 PMID: 11739249
Arai Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 1993 PMID: 8240400

HA 1100 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2415

Key Product Details

Biological Activity for HA 1100 hydrochloride

Technical Data for HA 1100 hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for HA 1100 hydrochloride

Product Documents for HA 1100 hydrochloride

COA

Certificate of Analysis

SDS

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