GTS 21 dihydrochloride

Name: GTS 21 dihydrochloride
Brand: Tocris Bioscience
SKU: 4557

Tocris Bioscience, part of Bio-Techne | Catalog # 4557

COA / SDS

α7 nAChR partial agonist

Discontinued Product

4557 has been discontinued. View all Nicotinic (a7) Receptor Agonists products.

Key Product Details

Description:	α7 nAChR partial agonist
Alternative Names:	DMXBA
Chemical Name:	3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	381.3

View Full Technical Details for GTS 21 dihydrochloride

Technical Data
Citations

Biological Activity for GTS 21 dihydrochloride

GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT₃ antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation. Also has anti-inflammatory effects independent of α7 nAChRs.

Technical Data for GTS 21 dihydrochloride

M. Wt	381.3
Formula	C₁₉H₂₀N₂O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	156223-05-1
PubChem ID	122225
InChi Key	BXKYFUGAAFLYJL-UHFFFAOYSA-N
Smiles	COC(C=C3OC)=CC=C3\C=C1C(C2=CC=CN=C2)=NCCC/1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GTS 21 dihydrochloride

References are publications that support the biological activity of the product.

Garg and Loring GTS-21 has cell-specific anti-inflammatory effects independent of a7 nicotinic acetylcholine receptors. PLoS One 2019 PMID: 30947238
Meyer Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res.
Olincy Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 2012 PMID: 23027417
Stevens Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 2010 PMID: 20599427

GTS 21 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4557

Key Product Details

Biological Activity for GTS 21 dihydrochloride

Technical Data for GTS 21 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GTS 21 dihydrochloride

Product Documents for GTS 21 dihydrochloride

COA

Certificate of Analysis

SDS

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