GSK2578215A
Tocris Bioscience, part of Bio-Techne | Catalog # 4629
Potent, selective LRRK2 inhibitor; brain penetrant
Key Product Details
Description
Potent, selective LRRK2 inhibitor; brain penetrant
Product Description
GSK2578215A is a potent LRRK2 inhibitor (IC50 values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 over a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
399.42
Formula
C24H18FN3O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
CAS Number
1285515-21-0
PubChem ID
68107965
InChI Key
WCIGMFCFPXZRMQ-UHFFFAOYSA-N
SMILES
FC1=NC=CC(C2=CC=C(OCC3=CC=CC=C3)C(C(NC4=CC=CN=C4)=O)=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.94 | 100 |
Preparing Stock Solutions
for GSK2578215A
The following data is based on the product molecular weight 399.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.52 mL | 25.04 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Reith GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substituent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg.Med.Chem.Lett. 2012 PMID: 22863203
Product Specific Notices for GSK2578215A
For research use only
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