GSK 650394

Tocris Bioscience, part of Bio-Techne | Catalog # 3572

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
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Key Product Details

Description

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

View all Other Kinase Inhibitors »

Product Description

GSK 650394 is a serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 μM).

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications

Molecular Weight

382.45

Formula

C25H22N2O2

Storage

Store at RT

Purity

≥97% (HPLC)

Chemical Name

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid

CAS Number

890842-28-1

PubChem ID

25022668

InChI Key

WVSBGSNVCDAMCF-UHFFFAOYSA-N

SMILES

O=C(C(C(C5CCCC5)=C4)=CC=C4C2=CNC1=NC=C(C3=CC=CC=C3)C=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100

Preparing Stock Solutions for GSK 650394

The following data is based on the product molecular weight 382.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 650394

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 650394

For research use only

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