GSK 4716
Tocris Bioscience, part of Bio-Techne | Catalog # 3075
Selective ERRγ and ERRβ agonist
Discontinued Product
3075 has been discontinued.
View all Estrogen and Related Receptor Agonists products.
Key Product Details
Description
Selective ERRγ and ERRβ agonist
Alternative Names
GW4716
Product Description
GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.Product Specifications
Molecular Weight
282.34
Formula
C17H18N2O2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
CAS Number
101574-65-6
PubChem ID
5331325
InChI Key
IKPPIUNQWSRCOZ-WOJGMQOQSA-N
SMILES
OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 100 | |
| Ethanol | 28.23 | 100 |
Preparing Stock Solutions
for GSK 4716
The following data is based on the product molecular weight 282.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ariazi and Jordan Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 2006 PMID: 16515477
- Wang X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 2006 PMID: 16990259
- Zuercher Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 2005 PMID: 15857113
Product Specific Notices for GSK 4716
For research use only
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