GSK 2833503A
Tocris Bioscience, part of Bio-Techne | Catalog # 6497
Potent and selective TRPC6 and TRPC3 antagonist
Key Product Details
Description
Potent and selective TRPC6 and TRPC3 antagonist
Product Description
GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.Product Specifications
Molecular Weight
381.89
Formula
C18H21ClFN3OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone
CAS Number
1366234-01-6
PubChem ID
71818575
InChI Key
ODUIXUGXPFKQLG-QWRGUYRKSA-N
SMILES
C[C@H]1CCCN(C(C2=C(SC(NC3=C(C=C(C=C3)Cl)F)=N2)C)=O)[C@H]1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.19 | 100 | |
| Ethanol | 7.64 | 20 |
Preparing Stock Solutions
for GSK 2833503A
The following data is based on the product molecular weight 381.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.09 mL | 26.19 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seo Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24453217
- Washburn The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg.Med.Chem.Lett. 2013 PMID: 23886683
Product Specific Notices for GSK 2833503A
For research use only
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