GS 6201

Tocris Bioscience, part of Bio-Techne | Catalog # 4727

Selective A2B antagonist
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Key Product Details

Description

Selective A2B antagonist

Alternative Names

CVT 6883

View all Adenosine A2b Receptor Antagonists »

Product Description

GS 6201 is a selective antagonist of adenosine A2B receptors (Ki values are 22, 1070, 1940 and 3280 nM for human A2B, A3, A1 and A2A receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.

Product Specifications

Molecular Weight

446.43

Formula

C21H21F3N6O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione

CAS Number

752222-83-6

PubChem ID

11270783

InChI Key

KOYXXLLNCXWUNF-UHFFFAOYSA-N

SMILES

O=C(N(CC)C2=C1NC(C3=CN(CC4=CC=CC(C(F)(F)F)=C4)N=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.23 5

Preparing Stock Solutions for GS 6201

The following data is based on the product molecular weight 446.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 44.80 mL 224.00 mL 448.00 mL
0.25 mM 8.96 mL 44.80 mL 89.60 mL
0.5 mM 4.48 mL 22.40 mL 44.80 mL
2.5 mM 0.90 mL 4.48 mL 8.96 mL

Calculators

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Product Documents for GS 6201

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GS 6201

For research use only

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