GR 159897

Name: GR 159897
Brand: Tocris Bioscience
SKU: 1274

Tocris Bioscience, part of Bio-Techne | Catalog # 1274

Citations (6)

COA / SDS

Non-peptide, potent NK2 antagonist

Discontinued Product

1274 has been discontinued. View all NK2 Receptor Antagonists products.

Key Product Details

Description:	Non-peptide, potent NK₂ antagonist
Chemical Name:	5-Fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulphinyl]methyl]-1-piperidinyl]ethyl]-1H-indole
Purity:	≥97% (HPLC)
Molecular Weight:	414.54

View Full Technical Details for GR 159897

Technical Data
Citations

Biological Activity for GR 159897

GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK₂ receptor antagonist. Competes for binding of [³H]GR100679 to hNK₂-transfected CHO cells with a pK_i of 9.5. Inhibits NK₂ receptor-mediated contraction of guinea pig trachea with a pA₂ of 8.7. Anxiolytic in vivo.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for GR 159897

M. Wt	414.54
Formula	C₂₃H₂₇FN₂O₂S
Storage	Desiccate at -20°C
Purity	≥97% (HPLC)
CAS Number	158848-32-9
PubChem ID	9953599
InChi Key	BANYJBHWTOJQDU-GDLZYMKVSA-N
Smiles	FC1=CC=C2C(C(CCN3CCC(C[S@@+]([O-])C4=CC=CC=C4)(OC)CC3)=CN2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GR 159897

References are publications that support the biological activity of the product.

Walsh The anxiolytic-like activity of GR 159897, a non-peptide NK₂ receptor antagonist, in rodent and primate models of anxiety. Psychopharmacology 1995 PMID: 8545524
Cooper GR 159897 and related analogues as highly potent, orally active non-peptide neurokinin NK₂ receptor antagonists. Bioorg.Med.Chem.Lett.
Beresford GR 159897, a potent non-peptide antagonist at tachykinin NK₂ receptors. Eur.J.Pharmacol. 1995 PMID: 7713168