FRAX 597
Tocris Bioscience, part of Bio-Techne | Catalog # 6029
Potent group I PAK inhibitor
Product Description
FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.Product Specifications
Molecular Weight
558.10
Formula
C29H28ClN7OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
CAS Number
1286739-19-2
PubChem ID
70934541
InChI Key
DHUJCQOUWQMVCG-UHFFFAOYSA-N
SMILES
CN(CC1)CCN1C2=CC=C(NC3=NC(N(CC)C(C(C4=CC=C(C5=CN=CS5)C=C4Cl)=C6)=O)=C6C=N3)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.16 | 20 |
Preparing Stock Solutions
for FRAX 597
The following data is based on the product molecular weight 558.10
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.96 mL | 44.79 mL | 89.59 mL |
| 1 mM | 1.79 mL | 8.96 mL | 17.92 mL |
| 2 mM | 0.90 mL | 4.48 mL | 8.96 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yeo FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcit. BMC Cancer 2016 PMID: 26774265
- Licciulli FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J.Biol.Chem. 2013 PMID: 23960073
Product Specific Notices for FRAX 597
For research use only
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