FR 139317

Tocris Bioscience, part of Bio-Techne | Catalog # 1210

Highly potent, selective ETA antagonist
Discontinued Product
1210 has been discontinued. View all Endothelin ETA Receptor Antagonists products.

Key Product Details

Description

Highly potent, selective ETA antagonist

View all Endothelin ETA Receptor Antagonists »

Product Description

FR 139317 is a highly potent and selective ETA endothelin receptor antagonist (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). Active in vivo.

Product Specifications

Molecular Weight

604.75

Formula

C33H44N6O5

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-D-alanine

CAS Number

142375-60-8

PubChem ID

107810

InChI Key

LIOKMIQQPDDTNO-UPRLRBBYSA-N

SMILES

O=C([C@H](CC(C)C)NC(N1CCCCCC1)=O)N[C@@H]([C@@](N[C@H](CC2=NC=CC=C2)C(O)=O)=O)CC(C3=CC=CC=C34)=CN4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 100
DMSO 100

Preparing Stock Solutions for FR 139317

The following data is based on the product molecular weight 604.75

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.65 mL 8.27 mL 16.54 mL
5 mM 0.33 mL 1.65 mL 3.31 mL
10 mM 0.17 mL 0.83 mL 1.65 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product.

Product Documents for FR 139317

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FR 139317

For research use only

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