Ferrostatin 1

Name: Ferrostatin 1
Brand: Tocris Bioscience
SKU: 5180
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5180

(1)

Citations (7)

COA / SDS

Selective inhibitor of erastin induced ferroptosis

Key Product Details

Description:	Selective inhibitor of erastin induced ferroptosis
Chemical Name:	Ethyl 3-amino-4-(cyclohexylamino)benzoate
Purity:	≥98% (HPLC)
Molecular Weight:	262.35

View Full Technical Details for Ferrostatin 1

Technical Data
Citations / Reviews (1)

Biological Activity for Ferrostatin 1

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC₅₀ = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Compound Libraries for Ferrostatin 1

Ferrostatin 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ferrostatin 1

M. Wt	262.35
Formula	C₁₅H₂₂N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	347174-05-4
PubChem ID	4068248
InChi Key	UJHBVMHOBZBWMX-UHFFFAOYSA-N
Smiles	O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ferrostatin 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.23	100
	ethanol	26.23	100

Preparing Stock Solutions for Ferrostatin 1

The following data is based on the product molecular weight 262.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.81 mL	19.06 mL	38.12 mL
5 mM	0.76 mL	3.81 mL	7.62 mL
10 mM	0.38 mL	1.91 mL	3.81 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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References for Ferrostatin 1

References are publications that support the biological activity of the product.

Louandre Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora. Int.J.Cancer 2013 PMID: 23505071
Skouta FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 2014 PMID: 24592866
Dixon Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012 PMID: 22632970