Epiblastin A

Name: Epiblastin A
Brand: Tocris Bioscience
SKU: 6340

Tocris Bioscience, part of Bio-Techne | Catalog # 6340

Citations (3)

COA / SDS

CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal

Discontinued Product

6340 has been discontinued. View all Casein Kinase 1 Inhibitors products.

Key Product Details

Description:	CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
Chemical Name:	6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
Purity:	≥98% (HPLC)
Molecular Weight:	287.71

View Full Technical Details for Epiblastin A

Technical Data
Citations

Biological Activity for Epiblastin A

Epiblastin A is a CK1 inhibitor (IC₅₀ values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

Compound Libraries for Epiblastin A

Epiblastin A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Epiblastin A

M. Wt	287.71
Formula	C₁₂H₁₀CIN₇
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	16470-02-3
PubChem ID	118987042
InChi Key	ZWNKKZSRANLVEW-UHFFFAOYSA-N
Smiles	NC1=NC2=NC(N)=C(C3=CC(Cl)=CC=C3)N=C2C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Epiblastin A

References are publications that support the biological activity of the product.

Ursu Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 2016 PMID: 27049670
Illich Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 2016 PMID: 27149845