Endomorphin-1

Name: Endomorphin-1
Brand: Tocris Bioscience
SKU: 1055

Tocris Bioscience, part of Bio-Techne | Catalog # 1055

Citations (17)

COA / SDS

Potent and selective μ agonist

Discontinued Product

1055 has been discontinued. View all mu Opioid Receptor Agonists products.

Key Product Details

Description:	Potent and selective μ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	610.67

View Full Technical Details for Endomorphin-1

Technical Data
Citations

Biological Activity for Endomorphin-1

Endomorphin-1 is a endogenous peptide with an exceptionally high affinity (K_i = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).

Technical Data for Endomorphin-1

M. Wt	610.67
Formula	C₃₄H₃₈N₆O₅
Single Letter Sequence	YPWF (Modification: Phe-4 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	189388-22-5
PubChem ID	5311080
InChi Key	ZEXLJFNSKAHNFH-SYKYGTKKSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Endomorphin-1

References are publications that support the biological activity of the product.

Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409
Harrison Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 1998 PMID: 9622031
Kakizawa Parallel stimulations of in vitro and in situ [³⁵S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 1998 PMID: 9622032
Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962

Endomorphin-1

Tocris Bioscience, part of Bio-Techne | Catalog # 1055

Key Product Details

Biological Activity for Endomorphin-1

Technical Data for Endomorphin-1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Endomorphin-1

Product Documents for Endomorphin-1

COA

Certificate of Analysis

SDS

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