Dooku 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6568

Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
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Key Product Details

Description

Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

View all Other Piezo Channel Compounds »

Product Description

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Product Specifications

Molecular Weight

326.20

Formula

C13H9Cl2N3OS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

CAS Number

2253744-54-4

PubChem ID

137321150

InChI Key

MNPOBXLPCWFONX-UHFFFAOYSA-N

SMILES

ClC1=C(CSC2=NN=C(O2)C3=CC=CN3)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.62 100

Preparing Stock Solutions for Dooku 1

The following data is based on the product molecular weight 326.20

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.33 mL 30.66 mL
5 mM 0.61 mL 3.07 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Dooku 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dooku 1

For research use only

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