(±)-ML 209

Name: (±)-ML 209
Brand: Tocris Bioscience
SKU: 5987

Tocris Bioscience, part of Bio-Techne | Catalog # 5987

COA / SDS

RORγt inverse agonist; suppresses Th17 cell differentiation

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Technical Data
Citations

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

RORγt inverse agonist; suppresses Th17 cell differentiation

View all ROR / NR1F Inverse Agonists »

Product Description

(±)-ML 209 is a RORγt inverse agonist (IC₅₀ = 460 nM). Suppresses Th₁₇ cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC₅₀ values >4.4 μM).

Product Specifications

Molecular Weight

441.52

Formula

C₂₅H₃₁NO₆

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(1,3-Benzodioxol-5-yl)-1-(cis-3,5-dimethyl-1-piperidinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone

CAS Number

1334526-14-5

PubChem ID

53385590

InChI Key

YEKVAIMYYCZDLI-MCPYQZEQSA-N

SMILES

COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.15	100

Preparing Stock Solutions for (±)-ML 209

The following data is based on the product molecular weight 441.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Wang Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg.Med.Chem. 2014 PMID: 24388993
Huang DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 2015 PMID: 26675721
Kojetin REV-ERB and ROR nuclear receptors as drug targets. Nat.Rev.Drug Discov. 2014 PMID: 24577401
Huang Identification of Potent and Selective RORγ Antagonists. Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 23658948