(±)-J 113397

Name: (±)-J 113397
Brand: Tocris Bioscience
SKU: 2598

Tocris Bioscience, part of Bio-Techne | Catalog # 2598

Citations (24)

COA / SDS

Potent and selective NOP antagonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective NOP antagonist

View all NOP Receptor Antagonists »

Product Description

(±)-J 113397 is a potent and selective NOP receptor antagonist (IC₅₀ values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

Product Specifications

Molecular Weight

399.57

Formula

C₂₄H₃₇N₃O₂

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one

CAS Number

217461-40-0

PubChem ID

90488772

InChI Key

NLSVMRCGZVSAFK-SDNSQTLOSA-N

SMILES

CCN1C4=C(C=CC=C4)N([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)C1=O.CCN5C8=C(C=CC=C8)N([C@H]6CCN(CC7CCCCCCC7)C[C@@H]6CO)C5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.98	50
	Ethanol	19.98	50

Preparing Stock Solutions for (±)-J 113397

The following data is based on the product molecular weight 399.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.01 mL	25.03 mL	50.05 mL
2.5 mM	1.00 mL	5.01 mL	10.01 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Ozaki In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur.J.Pharmacol. 2000 PMID: 10940356
Marti The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental Parkinsonism through overinhibition of nigrothalamic pathway. J.Neurosci. 2007 PMID: 17287504
Kawamoto Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J.Med.Chem. 1999 PMID: 10602690