Nociceptin

Name: Nociceptin
Brand: Tocris Bioscience
SKU: 0910

Tocris Bioscience, part of Bio-Techne | Catalog # 0910

Citations (96)

COA / SDS

Endogenous NOP agonist

Key Product Details

Description:	Endogenous NOP agonist
Alternative Names:	Orphanin FQ
Purity:	≥95% (HPLC)
Molecular Weight:	1809

View Full Technical Details for Nociceptin

Technical Data
Citations

Biological Activity for Nociceptin

Nociceptin is an endogenous ligand for the NOP opioid receptor (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i < 6).

Technical Data for Nociceptin

M. Wt	1809
Formula	C₇₉H₁₂₉N₂₇O₂₂
Single Letter Sequence	FGGFTGARKSARKLANQ
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	170713-75-4
PubChem ID	16131448
InChi Key	PULGYDLMFSFVBL-SMFNREODSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nociceptin

Solubility

Soluble to 1mg/ml in water

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References for Nociceptin

References are publications that support the biological activity of the product.

Meunier Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor. Nature 1995 PMID: 7566152
Henderson and McKnight The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 1997 PMID: 9277133
Reinscheid Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 1995 PMID: 7481766
Guerrini Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 2000 PMID: 10998526