Deschloroclozapine

Product Description

Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (K_i values are 6.3 nM for hM₃D_q and 4.2 nM for hM₄D_i, in vitro; EC₅₀ values are 0.13 nM for hM₃D_q and 0.081 nM for hM₄D_i, in vitro). Derivative of clozapine (Cat. No. 0444). Exhibits 100-fold greater affinity for hM₃D_q and hM₄D_i compared to clozapine N-oxide (CNO; Cat. No. 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat. No. 5548). Displays low 'off-target' receptor binding (K_i >100 nM at majority of GPCRs, ion channels and transporters tested). Displays rapid (approx. 10 minutes after i.p injection) binding and activation of hM₃D_q and hM₄D_i in mice and non-human primates. Induces spatial memory deficits in non-human primates expressing hM₄D_i in the prefrontal cortex.

Solubility

Preparing Stock Solutions for Deschloroclozapine

The following data is based on the product molecular weight 292.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.10 mL	34.20 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nagai Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys Nat.Neurosci. 2020 PMID: 32632286