DCA

Name: DCA
Brand: Tocris Bioscience
SKU: 2755

Catalog # 2755 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor

Key Product Details

Description:	Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
Chemical Name:	Sodium dichloroacetate
Molecular Weight:	150.92

View Full Technical Details for DCA

Technical Data
Citations / Reviews

Biological Activity for DCA

DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K_V1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Technical Data for DCA

M. Wt	150.92
Formula	C₂HCl₂NaO₂
Storage	Desiccate at RT
CAS Number	2156-56-1
PubChem ID	517326
InChi Key	LUPNKHXLFSSUGS-UHFFFAOYSA-M
Smiles	[Na+].[O-]C(=O)C(Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DCA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	15.09	100
	DMSO	15.09	100

Preparing Stock Solutions for DCA

The following data is based on the product molecular weight 150.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.63 mL	33.13 mL	66.26 mL
5 mM	1.33 mL	6.63 mL	13.25 mL
10 mM	0.66 mL	3.31 mL	6.63 mL
50 mM	0.13 mL	0.66 mL	1.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for DCA

References are publications that support the biological activity of the product.

Bonnet A mitochondria-K⁺ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007 PMID: 17222789
Bowker-kinley Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem.J. 1998 PMID: 9405293
Stacpoole The pharmacology of dichloroacetate. Metabolism Clin.Exp.

Citations for DCA

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.

DCA