DAU 5884 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2096
M3 receptor antagonist
Discontinued Product
2096 has been discontinued.
View all mAChR M3 Antagonists products.
Product Description
DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.Product Specifications
Molecular Weight
351.83
Formula
C17H21N3O3.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
CAS Number
131780-48-8
PubChem ID
16759154
InChI Key
FDERDDSQHZRNGC-LIWIJTDLSA-N
SMILES
Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)N1CC2=C(NC1=O)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.59 | 50 | |
| DMSO | 35.18 | 100 |
Preparing Stock Solutions
for DAU 5884 hydrochloride
The following data is based on the product molecular weight 351.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gosens Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype. Br.J.Pharmacol. 2004 PMID: 14993104
- Roffel Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors. Eur.J.Pharmacol. 1993 PMID: 8112384
- Gosens Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am.J.Respir.Cell Mol.Biol. 2003 PMID: 12540494
- Doods Characterization of muscarinic receptors in guinea-pig uterus. Eur.J.Pharmacol. 1993 PMID: 8112383
Product Specific Notices for DAU 5884 hydrochloride
For research use only
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