DAPTA

Name: DAPTA
Brand: Tocris Bioscience
SKU: 2423

Tocris Bioscience, part of Bio-Techne | Catalog # 2423

Citations (19)

COA / SDS

Chemokine receptor 5 (CCR5) antagonist

Discontinued Product

2423 has been discontinued. View all Chemokine Receptor Antagonists products.

Key Product Details

Description:	Chemokine receptor 5 (CCR5) antagonist
Alternative Names:	D-Ala-peptide T-amide
Molecular Weight:	856.89

View Full Technical Details for DAPTA

Technical Data
Citations

Biological Activity for DAPTA

DAPTA is a chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data for DAPTA

M. Wt	856.89
Formula	C₃₅H₅₆N₁₀O₁₅
Single Letter Sequence	ASTTTNYT (Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	106362-34-9
PubChem ID	184644
InChi Key	AKWRNBWMGFUAMF-ZESMOPTKSA-N
Smiles	[H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DAPTA

References are publications that support the biological activity of the product.

Rosi Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 2005 PMID: 15979806
Polianova Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 PMID: 16002156
Ruff Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 2003 PMID: 15043212

DAPTA

Tocris Bioscience, part of Bio-Techne | Catalog # 2423

Key Product Details

Biological Activity for DAPTA

Technical Data for DAPTA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DAPTA

Product Documents for DAPTA

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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