DAPTA

Catalog # 2423 | Tocris Bioscience a Bio-Techne Brand

Chemokine receptor 5 (CCR5) antagonist

Key Product Details

Description:	Chemokine receptor 5 (CCR5) antagonist
Alternative Names:	D-Ala-peptide T-amide
Molecular Weight:	856.89

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Technical Data
Citations / Reviews

Biological Activity for DAPTA

DAPTA is a chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data for DAPTA

M. Wt	856.89
Formula	C₃₅H₅₆N₁₀O₁₅
Single Letter Sequence	ASTTTNYT (Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	106362-34-9
PubChem ID	184644
InChi Key	AKWRNBWMGFUAMF-ZESMOPTKSA-N
Smiles	[H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DAPTA

Solubility

Soluble to 1mg/ml in water

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References for DAPTA

References are publications that support the biological activity of the product.

Rosi Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 2005 PMID: 15979806
Polianova Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 PMID: 16002156
Ruff Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 2003 PMID: 15043212

Citations for DAPTA

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