(D)-PPA 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6515
PD-1/PD-L1 interaction inhibitor
Discontinued Product
6515 has been discontinued.
View all Additional Apoptosis-related Compounds products.
Key Product Details
Description
PD-1/PD-L1 interaction inhibitor
Product Description
(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.Product Specifications
Molecular Weight
1555.67
Formula
C70H98N20O21
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
1620813-53-7
PubChem ID
134160249
InChI Key
ZEZZLZKHZPMELC-SDQLLZIZSA-N
SMILES
[H]N[C@H](CC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Chang Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 2015 PMID: 26259671
Product Specific Notices for (D)-PPA 1
For research use only
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