D 4476
Tocris Bioscience, part of Bio-Techne | Catalog # 2902
Selective CK1 inhibitor. Also inhibits TGF-βRI
Key Product Details
Description
Selective CK1 inhibitor. Also inhibits TGF-βRI
Product Description
D 4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.Licensing Information
Sold with the permission of GlaxoSmithKlineProduct Specifications
Molecular Weight
398.41
Formula
C23H18N4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
CAS Number
301836-43-1
PubChem ID
6419753
InChI Key
DPDZHVCKYBCJHW-UHFFFAOYSA-N
SMILES
O=C(N)C4=CC=C(C=C4)C1=NC(C2=CC(OCCO5)=C5C=C2)=C(C3=NC=CC=C3)N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.84 | 100 | |
| Ethanol | 19.92 | 50 |
Preparing Stock Solutions
for D 4476
The following data is based on the product molecular weight 398.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.10 mL |
| 5 mM | 0.50 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rena D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 PMID: 14710188
- Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214
- Callahan Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5). J.Med.Chem. 2002 PMID: 11855979
Product Specific Notices for D 4476
For research use only
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