Cytarabine
Tocris Bioscience, part of Bio-Techne | Catalog # 4520
Nucleoside analog; inhibits DNA replication
Key Product Details
Description
Nucleoside analog; inhibits DNA replication
Alternative Names
Cytosine b-D-arabinofuranoside
Product Description
Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.Product Specifications
Molecular Weight
243.22
Formula
C9H13N3O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
CAS Number
147-94-4
PubChem ID
114682
InChI Key
UHDGCWIWMRVCDJ-STUHELBRSA-N
SMILES
O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.32 | 100 | |
| DMSO | 12.16 | 50 |
Preparing Stock Solutions
for Cytarabine
The following data is based on the product molecular weight 243.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.11 mL | 20.56 mL | 41.12 mL |
| 5 mM | 0.82 mL | 4.11 mL | 8.22 mL |
| 10 mM | 0.41 mL | 2.06 mL | 4.11 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Breistøl Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models. Cancer Res. 1999 PMID: 10383159
- Yang Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 1986 PMID: 2954403
- Sampath Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 2006 PMID: 16293603
Product Specific Notices for Cytarabine
For research use only
⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Loading...
Loading...
Loading...