Cucurbitacin I
Tocris Bioscience, part of Bio-Techne | Catalog # 1571
Selective inhibitor of STAT3/JAK2 signaling
Discontinued Product
1571 has been discontinued.
View all JAK Kinase Inhibitors products.
Key Product Details
Description
Selective inhibitor of STAT3/JAK2 signaling
Alternative Names
Elatericin B,JSI 124
Product Description
Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.Product Specifications
Molecular Weight
514.65
Formula
C30H42O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
CAS Number
2222-07-3
PubChem ID
5281321
InChI Key
NISPVUDLMHQFRQ-MKIKIEMVSA-N
SMILES
OC(C)(C)/C=C/C([C@@](O)(C)[C@@]3([H])[C@H](O)C[C@@]([C@@](C)3C4)(C)[C@]2([H])CC=C1C(C)(C)C(C(O)=C[C@]([H])1[C@@](C)2C4=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.15 | 10 |
Preparing Stock Solutions
for Cucurbitacin I
The following data is based on the product molecular weight 514.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.43 mL | 97.15 mL | 194.31 mL |
| 0.5 mM | 3.89 mL | 19.43 mL | 38.86 mL |
| 1 mM | 1.94 mL | 9.72 mL | 19.43 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nefedova Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 2005 PMID: 16230418
- Dziennis Role of signal transducer and activator of transcription-3 in OE-mediated neuroprotection. J.Neurosci. 2007 PMID: 17611279
- Blaskovich Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003 PMID: 12649187
Product Specific Notices for Cucurbitacin I
For research use only
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