CoraFluor™ 2, Haloalkane

Tocris Bioscience, part of Bio-Techne | Catalog # 8818

Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand
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Key Product Details

Description

Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand

View all TR-FRET and FP Assay Reagents »

Product Description

CoraFluor™ 2, Haloalkane is a cell permeable terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for live cell TR-FRET assay development, such as target engagement and ternary complex assays. CoraFluor™ 2, Haloalkane is designed with a chloroalkane ligand for reactivity with haloalkane dehalogenase labeled proteins. CoraFluor™ 2, Haloalkane can be used in live cell intracellular TR-FRET assays. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 2, Haloalkane displays red shifted excitation and is excitable by both 365 nm and 405 nm lasers. It is compatible with common acceptor dyes such as FAM/FITC, AF488, GFP, mCherry, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.

CoraFluor™ 1, Haloalkane, CoraFluor™ 1, thiol reactive, CoraFluor™ 1, amine reactive and CoraFluor™ 2, amine reactive also available.

For more information, please see our CoraFluor™ TR-FRET technology flyer .

CoraFluor™ is a trademark of Bio-Techne Corp.

Scientific Data Images for CoraFluor™ 2, Haloalkane

Live cell TR-FRET assay

Live cell TR-FRET assay.

Cellular dose-dependent inhibition of HDAC1-dehalogenase fusion protein labeled with CoraFluor™ 2, Haloalkane in HEK293T cells by various HDAC inhibitors (treatment for 4 h at 37 °C, 1 μM SAHA-NCT).

Licensing Information

Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Optical Data

λabs 356 nm
Extinction Coefficient (ε) 15900 M-1cm-1
Quantum Yield (φ) 0.35
Closest Laser line 337 nm
Cell Permeable Yes
Application Time-resolved fluorescence energy transfer (TR-FRET)

Product Specifications

Molecular Weight

1662.70

Storage

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for CoraFluor™ 2, Haloalkane

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CoraFluor™ 2, Haloalkane

For research use only

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