Chelerythrine chloride

Name: Chelerythrine chloride
Brand: Tocris Bioscience
SKU: 1330

Tocris Bioscience, part of Bio-Techne | Catalog # 1330

Citations (50)

COA / SDS

Cell-permeable protein kinase C inhibitor

Key Product Details

Description:	Cell-permeable protein kinase C inhibitor
Chemical Name:	1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	383.83

View Full Technical Details for Chelerythrine chloride

Technical Data
Citations

Biological Activity for Chelerythrine chloride

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

Technical Data for Chelerythrine chloride

M. Wt	383.83
Formula	C₂₁H₁₈ClNO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	3895-92-9
PubChem ID	72311
InChi Key	WEEFNMFMNMASJY-UHFFFAOYSA-M
Smiles	C[N+](C3=C2C=CC4=C3C=C(OCO5)C5=C4)=CC1=C2C=CC(OC)=C1OC.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chelerythrine chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.84	10
	DMSO	3.84	10

Preparing Stock Solutions for Chelerythrine chloride

The following data is based on the product molecular weight 383.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.05 mL	130.27 mL	260.53 mL
0.5 mM	5.21 mL	26.05 mL	52.11 mL
1 mM	2.61 mL	13.03 mL	26.05 mL
5 mM	0.52 mL	2.61 mL	5.21 mL

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References for Chelerythrine chloride

References are publications that support the biological activity of the product.

Yu Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 2000 PMID: 10734112
Herbert Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 1990 PMID: 2244923
Lee Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 1998 PMID: 9677417
Chan Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 2003 PMID: 12702731