Chelerythrine chloride

Name: Chelerythrine chloride
Brand: Tocris Bioscience
SKU: 1330

Catalog # 1330 | Tocris Bioscience a Bio-Techne Brand

Citations (17)

COA / SDS

Cell-permeable protein kinase C inhibitor

Key Product Details

Description:	Cell-permeable protein kinase C inhibitor
Chemical Name:	1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	383.83

View Full Technical Details for Chelerythrine chloride

Technical Data
Citations (17) / Reviews

Biological Activity for Chelerythrine chloride

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

Technical Data for Chelerythrine chloride

M. Wt	383.83
Formula	C₂₁H₁₈ClNO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	3895-92-9
PubChem ID	72311
InChi Key	WEEFNMFMNMASJY-UHFFFAOYSA-M
Smiles	C[N+](C3=C2C=CC4=C3C=C(OCO5)C5=C4)=CC1=C2C=CC(OC)=C1OC.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chelerythrine chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.84	10
	DMSO	3.84	10

Preparing Stock Solutions for Chelerythrine chloride

The following data is based on the product molecular weight 383.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.05 mL	130.27 mL	260.53 mL
0.5 mM	5.21 mL	26.05 mL	52.11 mL
1 mM	2.61 mL	13.03 mL	26.05 mL
5 mM	0.52 mL	2.61 mL	5.21 mL

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References for Chelerythrine chloride

References are publications that support the biological activity of the product.

Chan Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 2003 PMID: 12702731
Yu Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 2000 PMID: 10734112
Lee Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 1998 PMID: 9677417
Herbert Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 1990 PMID: 2244923

Citations for Chelerythrine chloride (17)

Showing 1 - 10 of 17 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Chelerythrine chloride include:

Livingstone et al. (2019) Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 12:198
PMID: 31474829
Martín-Segura et al. (2019) Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. Front Neurol. 10:675
PMID: 31293510
Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep. 7(1):15317
PMID: 29127424
Ortinski et al. (2015) Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 DA receptor-expressing neurons. Neuropharmacology. 92:80
PMID: 25596492
Morelli et al. (2014) Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer. 14:921
PMID: 25481381
Liu and Zhuo (2014) Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 10:1
PMID: 24398034
Most et al. (2013) S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res. 112:66
PMID: 23048072
Gosselin et al. (2013) Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation. Front Cell Neurosci. 7:251
PMID: 24368897
Cho et al. (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 32:14165
PMID: 23055486
Mockett et al. (2011) Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. J Neurosci. 31:7380
PMID: 21593322
Chen et al. (2011) mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci. 18:19
PMID: 21342491
Fuortes et al. (2010) Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Epilepsia. 51:1633
PMID: 20659148
Song et al. (2010) Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction. ACS Chem Neurosci. 85:614
PMID: 19797427
Jin and Yu (2010) Involvement of protein kinase C in mor. tolerance at spinal levels of rats. Autophagy. 1:122
PMID: 22778820
Xu et al. (2010) The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin. Exp Neurol. 222:93
PMID: 20036240
Xie and Wang (2009) Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension. 54:1298
PMID: 19858408
Xu et al. (2009) Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. Cardiovasc Res. 87:482
PMID: 18752301

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