CHC

Tocris Bioscience, part of Bio-Techne | Catalog # 5029

COA / SDS

MCT inhibitor; decreases glycoloysis

Key Product Details

Description:	MCT inhibitor; decreases glycoloysis
Chemical Name:	2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	189.17

View Full Technical Details for CHC

Technical Data
Citations

Biological Activity for CHC

CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

Compound Libraries for CHC

CHC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CHC

M. Wt	189.17
Formula	C₁₀H₇NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	28166-41-8
PubChem ID	5328791
InChi Key	AFVLVVWMAFSXCK-VMPITWQZSA-N
Smiles	OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.92	100
	ethanol	3.78	20

Preparing Stock Solutions for CHC

The following data is based on the product molecular weight 189.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.43 mL	52.86 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

Molarity Calculator

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Reconstitution Calculator

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References for CHC

References are publications that support the biological activity of the product.

Colen Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery 2006 PMID: 17277695
Fang The H⁺-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol.Pharmacol. 2006 PMID: 17000864
Dimmer The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem.J. 2000 PMID: 10926847
Miranda-Gonçalves Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro.Oncol. 2013 PMID: 23258846

CHC