CH 275
Tocris Bioscience, part of Bio-Techne | Catalog # 2454
Potent and selective sst1 agonist
Discontinued Product
2454 has been discontinued.
View all Somatostatin Receptor Agonists products.
Key Product Details
Description
Potent and selective sst1 agonist
Product Description
CH 275 is a potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens.Licensing Information
Sold with the permission of the SALK Institute.Product Specifications
Molecular Weight
1485.80
Formula
C74H96N14O15S2
Storage
Store at -20°C
CAS Number
174688-78-9
PubChem ID
90488765
InChI Key
LFOPEPKKBBIGHF-RXUBGYFDSA-N
SMILES
[H]N[C@H]1CSSC[C@H](NC[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](NC(=O)[C@@H](CC2=CC=C(CNC(C)C)C=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.3mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Rivier Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J.Med.Chem. 2001 PMID: 11405660
- Vasilaki The somatostatin receptor (sst1) modulates the release of somatostatin in the nucleus accumbens of the rat. Neuropharmacology 2004 PMID: 15380378
- Chen Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem.Biophys.Res.Commun. 1999 PMID: 10329447
Product Specific Notices for CH 275
For research use only
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