Cetirizine dihydrochloride

Name: Cetirizine dihydrochloride
Brand: Tocris Bioscience
SKU: 2577

Tocris Bioscience, part of Bio-Techne | Catalog # 2577

Citations (74)

COA / SDS

Selective H1 antagonist

Discontinued Product

2577 has been discontinued. View all Histamine H1 Receptor Antagonists products.

Key Product Details

Description:	Selective H₁ antagonist
Alternative Names:	P 071
Chemical Name:	[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	461.81

View Full Technical Details for Cetirizine dihydrochloride

Technical Data
Citations

Biological Activity for Cetirizine dihydrochloride

Cetirizine dihydrochloride is a histamine H₁ receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data for Cetirizine dihydrochloride

M. Wt	461.81
Formula	C₂₁H₂₅ClN₂O₃.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	83881-52-1
PubChem ID	55182
InChi Key	PGLIUCLTXOYQMV-UHFFFAOYSA-N
Smiles	Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Cetirizine dihydrochloride

References are publications that support the biological activity of the product.

Snowman and Snyder Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 1990 PMID: 1979798
Walsh Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 1991 PMID: 1682275
Campoli-Richards Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 1990 PMID: 1981354

Cetirizine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2577

Key Product Details

Biological Activity for Cetirizine dihydrochloride

Technical Data for Cetirizine dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Cetirizine dihydrochloride

Product Documents for Cetirizine dihydrochloride

COA

Certificate of Analysis

SDS

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