CD 2665

Name: CD 2665
Brand: Tocris Bioscience
SKU: 3800

Tocris Bioscience, part of Bio-Techne | Catalog # 3800

Citations (34)

COA / SDS

Selective RARβ/γ antagonist

Key Product Details

Description:	Selective RARβ/γ antagonist
Chemical Name:	4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	486.6

View Full Technical Details for CD 2665

Technical Data
Citations

Biological Activity for CD 2665

CD 2665 is a selective RARβγ antagonist (K_D values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.

Compound Libraries for CD 2665

CD 2665 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 2665

M. Wt	486.6
Formula	C₃₁H₃₄O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	170355-78-9
PubChem ID	216241
InChi Key	JBALRFFXKQPVLT-UHFFFAOYSA-N
Smiles	COCCOCOC(C(C3(CC5C4)CC(C5)CC4C3)=C2)=CC1=C2C=C(C6=CC=C(C(O)=O)C=C6)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD 2665

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.66	100

Preparing Stock Solutions for CD 2665

The following data is based on the product molecular weight 486.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.28 mL	20.55 mL
5 mM	0.41 mL	2.06 mL	4.11 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for CD 2665

References are publications that support the biological activity of the product.

Meister Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 1998 PMID: 9673404
Kim The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 2000 PMID: 10651997
Szondy Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 1997 PMID: 9187263