Cariporide

Name: Cariporide
Brand: Tocris Bioscience
SKU: 5358

Tocris Bioscience, part of Bio-Techne | Catalog # 5358

Citations (16)

COA / SDS

Selective NHE1 inhibitor; cardioprotective and antitumor

Key Product Details

Description:	Selective NHE1 inhibitor; cardioprotective and antitumor
Alternative Names:	HOE 642
Chemical Name:	N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	283.35

View Full Technical Details for Cariporide

Technical Data
Citations

Biological Activity for Cariporide

Cariporide is a selective Na⁺/H⁺ exchanger isoform 1 (NHE1) inhibitor (IC₅₀ values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

Compound Libraries for Cariporide

Cariporide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cariporide

M. Wt	283.35
Formula	C₁₂H₁₇N₃O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	159138-80-4
PubChem ID	151172
InChi Key	IWXNYAIICFKCTM-UHFFFAOYSA-N
Smiles	CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cariporide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.34	100

Preparing Stock Solutions for Cariporide

The following data is based on the product molecular weight 283.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.65 mL	35.29 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.76 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for Cariporide

References are publications that support the biological activity of the product.

Harguindey Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 2013 PMID: 24195657
Chakrabarti A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 1997 PMID: 9405190
Teshima Cariporide (HOE642), a selective Na⁺-H⁺ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 2003 PMID: 14568900
Scholz Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 1995 PMID: 7736504