Cariporide
Tocris Bioscience, part of Bio-Techne | Catalog # 5358
Selective NHE1 inhibitor; cardioprotective and antitumor
Key Product Details
Description
Selective NHE1 inhibitor; cardioprotective and antitumor
Alternative Names
HOE 642
Product Description
Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.Product Specifications
Molecular Weight
283.35
Formula
C12H17N3O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
CAS Number
159138-80-4
PubChem ID
151172
InChI Key
IWXNYAIICFKCTM-UHFFFAOYSA-N
SMILES
CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.34 | 100 |
Preparing Stock Solutions
for Cariporide
The following data is based on the product molecular weight 283.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.65 mL | 35.29 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harguindey Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 2013 PMID: 24195657
- Chakrabarti A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 1997 PMID: 9405190
- Teshima Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 2003 PMID: 14568900
- Scholz Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 1995 PMID: 7736504
Product Specific Notices for Cariporide
For research use only
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