Calphostin C

Name: Calphostin C
Brand: Tocris Bioscience
SKU: 1626

Tocris Bioscience, part of Bio-Techne | Catalog # 1626

Citations (55)

COA / SDS

Potent, selective and photo-dependent PKC inhibitor

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Technical Data
Citations

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent, selective and photo-dependent PKC inhibitor

Alternative Names

UCN 1028C,PKF 115584

View all Protein Kinase C Inhibitors »

Product Description

Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC₅₀ = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC₅₀ ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Product Specifications

Molecular Weight

790.76

Formula

C₄₄H₃₈O₁₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

CAS Number

121263-19-2

PubChem ID

6604893

InChI Key

SRJYZPCBWDVSGO-NHCUHLMSSA-N

SMILES

O=C1C(OC)=C(C[C@@H](C)OC(C2=CC=CC=C2)=O)C3=C4C5=C(C(OC)=CC(O)=C5C(C(OC)=C4C[C@@H](C)OC(OC6=CC=C(O)C=C6)=O)=O)C7=C(OC)C=C(O)C1=C73

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Matsuzaki and Darcha In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 2013 PMID: 23626717
Au Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 2006 PMID: 16829117
Kobayashi Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm.
Pollack and Kawecki The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 1997 PMID: 9049854