Bromosporine
Tocris Bioscience, part of Bio-Techne | Catalog # 4758
Broad spectrum bromodomain inhibitor
Key Product Details
Description
Broad spectrum bromodomain inhibitor
Product Description
Bromosporine is a broad spectrum bromodomain inhibitor. Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the Bromosporine probe summary on the SGC website.Product Specifications
Molecular Weight
404.44
Formula
C17H20N6O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
CAS Number
1619994-69-2
PubChem ID
72943187
InChI Key
UYBRROMMFMPJAN-UHFFFAOYSA-N
SMILES
CC1=C(NS(=O)(C)=O)C=C(C3=NN2C(C(NC(OCC)=O)=C3)=NN=C2C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.44 | 100 |
Preparing Stock Solutions
for Bromosporine
The following data is based on the product molecular weight 404.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gallenkamp Bromodomains and their pharmacological inhibitors. ChemMedChem 2014 PMID: 24497428
Product Specific Notices for Bromosporine
For research use only
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