BIO-acetoxime

Name: BIO-acetoxime
Brand: Tocris Bioscience
SKU: 3874

Tocris Bioscience, part of Bio-Techne | Catalog # 3874

Citations (10)

COA / SDS

Selective GSK-3α/β inhibitor

Discontinued Product

3874 has been discontinued. View all GSK-3 Inhibitors products.

Key Product Details

Description:	Selective GSK-3α/β inhibitor
Chemical Name:	(2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
Purity:	≥98% (HPLC)
Molecular Weight:	398.21

View Full Technical Details for BIO-acetoxime

Technical Data
Citations

Biological Activity for BIO-acetoxime

BIO-acetoxime is a selective GSK-3α/β inhibitor (IC₅₀ values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Data for BIO-acetoxime

M. Wt	398.21
Formula	C₁₈H₁₂BrN₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	667463-85-6
PubChem ID	24906283
InChi Key	ORWSYHWTBSHFIV-UHFFFAOYSA-N
Smiles	O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BIO-acetoxime

References are publications that support the biological activity of the product.

Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 2004 PMID: 14761195
Gattinoni Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 2009 PMID: 19525962
Meijer GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633

BIO-acetoxime

Tocris Bioscience, part of Bio-Techne | Catalog # 3874

Key Product Details

Biological Activity for BIO-acetoxime

Technical Data for BIO-acetoxime

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BIO-acetoxime

Product Documents for BIO-acetoxime

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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