BIO-acetoxime

Tocris Bioscience, part of Bio-Techne | Catalog # 3874

Selective GSK-3α/β inhibitor
Discontinued Product
3874 has been discontinued. View all GSK-3 Inhibitors products.

Key Product Details

Description

Selective GSK-3α/β inhibitor

View all GSK-3 Inhibitors »

Product Description

BIO-acetoxime is a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Product Specifications

Molecular Weight

398.21

Formula

C18H12BrN3O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2'Z,3'E)-6-Bromoindirubin-3'-acetoxime

CAS Number

667463-85-6

PubChem ID

24906283

InChI Key

ORWSYHWTBSHFIV-UHFFFAOYSA-N

SMILES

O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.96 20

Preparing Stock Solutions for BIO-acetoxime

The following data is based on the product molecular weight 398.21

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.56 mL 62.78 mL 125.56 mL
1 mM 2.51 mL 12.56 mL 25.11 mL
2 mM 1.26 mL 6.28 mL 12.56 mL
10 mM 0.25 mL 1.26 mL 2.51 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for BIO-acetoxime

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIO-acetoxime

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.