BAZ2-ICR
Tocris Bioscience, part of Bio-Techne | Catalog # 5266
Selective BAZ2 inhibitor
Product Description
BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.Product Specifications
Molecular Weight
357.41
Formula
C20H19N7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
CAS Number
1665195-94-7
PubChem ID
91654625
InChI Key
RRZVGDGTWNQAPW-UHFFFAOYSA-N
SMILES
CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.74 | 100 | |
| Ethanol | 35.74 | 100 |
Preparing Stock Solutions
for BAZ2-ICR
The following data is based on the product molecular weight 357.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.80 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.80 mL | 5.60 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.80 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Drouin Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 2015 PMID: 25719566
Product Specific Notices for BAZ2-ICR
For research use only
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