BAY 299

Name: BAY 299
Brand: Tocris Bioscience
SKU: 5970

Tocris Bioscience, part of Bio-Techne | Catalog # 5970

Citations (2)

COA / SDS

Potent and selective BRD1 and TAF1 inhibitor

Key Product Details

Description:	Potent and selective BRD1 and TAF1 inhibitor
Chemical Name:	6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	429.47

View Full Technical Details for BAY 299

Technical Data
Citations

Biological Activity for BAY 299

BAY 299 is a potent and selective BRD1 and TAF1 inhibitor (IC₅₀ values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC₅₀ values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC₅₀ values are 825 nM and 1.4 μM, respectively).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 299 probe summary on the SGC website.

Compound Libraries for BAY 299

BAY 299 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 299 is reviewed on the Chemical Probes website.

Technical Data for BAY 299

M. Wt	429.47
Formula	C₂₅H₂₃N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2080306-23-4
PubChem ID	122705990
InChi Key	OFWWWKWUCDUISA-UHFFFAOYSA-N
Smiles	OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 299

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.95	100

Preparing Stock Solutions for BAY 299

The following data is based on the product molecular weight 429.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.28 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for BAY 299

References are publications that support the biological activity of the product.

Bouche Benzoisoquinolinediones as potent and selective inhibitors of BRPF2 and TAF1/TAF1L bromodomains. J.Med.Chem. 2017 PMID: 28402630
Klein Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics 2014 PMID: 24169304