Baicalein

Product Description

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC₅₀ values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G₁ and G₂ cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.

Solubility

Preparing Stock Solutions for Baicalein

The following data is based on the product molecular weight 270.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.40 mL	37.00 mL	74.01 mL
2.5 mM	1.48 mL	7.40 mL	14.80 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
25 mM	0.15 mL	0.74 mL	1.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Xie Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 2016 PMID: 27037021
• Hsieh Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 2007 PMID: 18039391
• Nakahata Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 2003 PMID: 12568909
• Sekiya and Okuda Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 1982 PMID: 6807310
• Hsu Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 2001 PMID: 11513834