β-Pompilidotoxin

Name: β-Pompilidotoxin
Brand: Tocris Bioscience
SKU: 1539

Tocris Bioscience, part of Bio-Techne | Catalog # 1539

COA / SDS

Slows neuronal Na+ channel inactivation

Discontinued Product

1539 has been discontinued. View all Additional Voltage-gated Sodium Channel Products products.

Key Product Details

Description:	Slows neuronal Na⁺ channel inactivation
Alternative Names:	β-PMTX
Molecular Weight:	1557.9

View Full Technical Details for β-Pompilidotoxin

Technical Data
Citations

Biological Activity for β-Pompilidotoxin

β-Pompilidotoxin is a novel wasp neurotoxin that slows Na⁺ channel inactivation. Facilitates neuromuscular synaptic transmission and discriminates between rat neuronal and cardiac Na⁺ channel α-subunits.

Licensing Information

Sold with the permission of Suntory Ltd.

Technical Data for β-Pompilidotoxin

M. Wt	1557.9
Formula	C₇₁H₁₂₄N₂₂O₁₇
Single Letter Sequence	RIKIGLFDQLSRL (Modifications: Leu-13 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	216064-36-7
PubChem ID	90479801
InChi Key	YBOJYGJMKPMNRC-QRIWDNSUSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for β-Pompilidotoxin

References are publications that support the biological activity of the product.

Konno Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. Biochem.Biophys.Res.Commun. 1998 PMID: 9784394
Miyawaki Differential effects of novel wasp toxin on rat hippocampal interneurons. Neurosci.Lett. 2002 PMID: 12123851
Kinoshita Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol.Pharmacol. 2001 PMID: 11353806