Auranofin

Name: Auranofin
Brand: Tocris Bioscience
SKU: 4600

Tocris Bioscience, part of Bio-Techne | Catalog # 4600

Citations (22)

COA / SDS

Thioredoxin reductase inhibitor; induces MPT

Discontinued Product

4600 has been discontinued. View all Other Reductase Inhibitors products.

Key Product Details

Description:	Thioredoxin reductase inhibitor; induces MPT
Chemical Name:	1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Molecular Weight:	678.48

View Full Technical Details for Auranofin

Technical Data
Citations

Biological Activity for Auranofin

Auranofin is an inhibitor of thioredoxin reductase (TrxR) (IC₅₀ = 20 nM; K_i = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations. Also inhibits SARS-CoV-2 infection in Huh7 cell line (IC₅₀ = 1.4 μM)

Technical Data for Auranofin

M. Wt	678.48
Formula	C₂₀H₃₄AuO₉PS
Storage	Store at RT
CAS Number	34031-32-8
PubChem ID	6918453
InChi Key	AUJRCFUBUPVWSZ-XTZHGVARSA-M
Smiles	CCP(CC)(CC)=[Au]S[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Auranofin

References are publications that support the biological activity of the product.

Rothan The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. Virology 2020 PMID: 32442105
Betts Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils. Biochem.Pharmacol. 1990 PMID: 2157444
Rigobello Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br.J.Pharmacol. 2002 PMID: 12163349
Gromer Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J.Biol.Chem. 1998 PMID: 9685351
Kim Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 2007 PMID: 17645497

Product Documents for Auranofin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Auranofin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov