Astressin

Name: Astressin
Brand: Tocris Bioscience
SKU: 1606

Tocris Bioscience, part of Bio-Techne | Catalog # 1606

Citations (21)

COA / SDS

Potent CRF antagonist

Key Product Details

Description:	Potent CRF antagonist
Alternative Names:	[D-Phe¹²,Nle^21,38,Glu³⁰,Lys³³]-CRF (12-41)
Purity:	≥95% (HPLC)
Molecular Weight:	3563.2

View Full Technical Details for Astressin

Technical Data
Citations

Biological Activity for Astressin

Astressin is a potent corticotropin-releasing factor (CRF) receptor antagonist (K_i values are 2, 1.5 and 1 nM at CRF₁, CRF₂_α and CRF₂_β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Astressin

M. Wt	3563.2
Formula	C₁₆₁H₂₆₉N₄₉O₄₂
Single Letter Sequence	FHLLREVLEXARAEQLAQEAHKNRKLXEII (Modifications: Phe-1 = D-Phe, X-10 = X-27 = Nle, Glu-19 = γ-Glu, Lys-22 = ε-Lys, Cyclized: Glu-19 - Lys-22, Ile-30 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	170809-51-5
PubChem ID	16133798
InChi Key	HPYIIXJJVYSMCV-MGDXKYBTSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Astressin

Solubility

Soluble to 1mg/ml in 10% Acetic acid / water

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References for Astressin

References are publications that support the biological activity of the product.

Perrin and Vale Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 1999 PMID: 10816663
Maecker Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 1997 PMID: 9030428
Martinez Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. J.Pharmacol.Exp.Ther. 1999 PMID: 10411571
Gulyas Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7479843