Asenapine maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 3737
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
Key Product Details
Description
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
Product Description
Asenapine maleate is a novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.Product Specifications
Molecular Weight
401.84
Formula
C17H16ClNO.C4H4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenzoxepino[4,5-c]pyrrole maleate
CAS Number
85650-56-2
PubChem ID
73416848
InChI Key
QGBIWSABMNWWNB-FGYPTBLJSA-N
SMILES
CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.18 | 100 | |
| Ethanol | 20.09 | 50 |
Preparing Stock Solutions
for Asenapine maleate
The following data is based on the product molecular weight 401.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meltzer Asenapine. Nat.Rev.Drug Discov. 2009 PMID: 19876039
- Marston Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 2009 PMID: 19462162
- Shahid Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 2009 PMID: 18308814
Product Specific Notices for Asenapine maleate
For research use only
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