AS 1892802
Tocris Bioscience, part of Bio-Techne | Catalog # 4927
Potent ROCK inhibitor; orally bioavailable
Discontinued Product
4927 has been discontinued.
View all Rho-kinase Inhibitors products.
Key Product Details
Description
Potent ROCK inhibitor; orally bioavailable
Product Description
AS 1892802 is a potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable.Product Specifications
Molecular Weight
333.38
Formula
C20H19N3O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea
CAS Number
928320-12-1
PubChem ID
46911016
InChI Key
WDTFYYZHMRBVHK-LJQANCHMSA-N
SMILES
O=C(N[C@H](CO)C3=CC=CC=C3)NC(C=C2)=CC=C2C1=CC=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.34 | 100 | |
| Ethanol | 8.33 | 25 |
Preparing Stock Solutions
for AS 1892802
The following data is based on the product molecular weight 333.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.00 mL | 15.00 mL | 30.00 mL |
| 5 mM | 0.60 mL | 3.00 mL | 6.00 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yoshimi Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 2010 PMID: 20534789
- Li Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 2012 PMID: 22272748
Product Specific Notices for AS 1892802
For research use only
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