Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC₅₀ = 12.0 μM) and ERK2 (IC₅₀ = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC₅₀ >100 μM). Arrests cell cycle at G2/M boundary (IC₅₀ = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Licensing Information

Sold under license from the Regents of the University of California

Product Specifications

Molecular Weight

403.91

Formula

C₁₉H₂₆ClN₇O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

CAS Number

220792-57-4

PubChem ID

6604931

InChI Key

RAMROQQYRRQPDL-HNNXBMFYSA-N

SMILES

ClC1=CC(N)=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.39	100

Preparing Stock Solutions for Aminopurvalanol A

The following data is based on the product molecular weight 403.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.38 mL	24.76 mL
5 mM	0.50 mL	2.48 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Background References

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Knockaert Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 2000 PMID: 10873834
Rosiana A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA
Chang Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 1999 PMID: 10375538

Aminopurvalanol A

Tocris Bioscience, part of Bio-Techne | Catalog # 2072

Key Product Details

Description

Alternative Names

View all Cyclin-dependent Kinase Inhibitors »

Product Description