AMG 837 hemicalcium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 6082
Potent FFA1 (GPR40) partial agonist
Key Product Details
Description
Potent FFA1 (GPR40) partial agonist
Product Description
AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.Product Specifications
Molecular Weight
457.47
Formula
C26H20F3O3.½Ca
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
CAS Number
1291087-14-3
PubChem ID
46854655
InChI Key
WCZAHGONZBHQSA-UHFFFAOYSA-L
SMILES
CC#C[C@H](C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)CC([O-])=O.CC#C[C@H](C4=CC=C(C=C4)OCC5=CC=CC(C6=CC=C(C(F)(F)F)C=C6)=C5)CC([O-])=O.[Ca+2]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.75 | 100 |
Preparing Stock Solutions
for AMG 837 hemicalcium salt
The following data is based on the product molecular weight 457.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lin Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 2012 PMID: 22859723
- Lin AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents. PLoS One 2011 PMID: 22087278
- Houze AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 2012 PMID: 22217876
Product Specific Notices for AMG 837 hemicalcium salt
For research use only
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