Ambroxol hydrochloride

Name: Ambroxol hydrochloride
Brand: Tocris Bioscience
SKU: 2404

Tocris Bioscience, part of Bio-Techne | Catalog # 2404

COA / SDS

Na+ channel blocker

Discontinued Product

2404 has been discontinued. View all Voltage-gated Sodium Channel Blockers products.

Key Product Details

Description:	Na⁺ channel blocker
Chemical Name:	trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	414.57

View Full Technical Details for Ambroxol hydrochloride

Technical Data
Citations

Biological Activity for Ambroxol hydrochloride

Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC₅₀ values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus.

Compound Libraries for Ambroxol hydrochloride

Ambroxol hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ambroxol hydrochloride

M. Wt	414.57
Formula	C₁₃H₁₈Br₂N₂O.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	23828-92-4
PubChem ID	108013
InChi Key	QNVKOSLOVOTXKF-UHFFFAOYSA-N
Smiles	NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ambroxol hydrochloride

References are publications that support the biological activity of the product.

Yang Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur.Respir.J. 2002 PMID: 12030738
Gibbs Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 1999 PMID: 10202994
Weiser and Wilson Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na⁺ channels by the secretolytic ambroxol. Mol.Pharmacol. 2002 PMID: 12181417
Gillissen Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 1997 PMID: 9195551