AG 825 is a selective ErbB2 inhibitor (IC₅₀ values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

Product Specifications

Molecular Weight

397.47

Formula

C₁₉H₁₅N₃O₃S₂

Storage

Store at +4°C

Chemical Name

3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide

CAS Number

149092-50-2

PubChem ID

6091659

InChI Key

KXDONFLNGBQLTN-WUXMJOGZSA-N

SMILES

COC1=CC(\C=C(/C#N)C(N)=O)=CC(CSC2=NC3=C(S2)C=CC=C3)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.75	100

Preparing Stock Solutions for AG 825

The following data is based on the product molecular weight 397.47

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Background References

References are publications that support the biological activity of the product.

Murillo Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21. Cancer Res. 2001 PMID: 11606371
Osherov Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J.Biol.Chem. 1993 PMID: 8098709
Gazit Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J.Med.Chem. 1993 PMID: 7902440

AG 825

Tocris Bioscience, part of Bio-Techne | Catalog # 1555

Key Product Details

Description

Alternative Names

View all EGF Receptor Inhibitors »

Product Description