ACDPP hydrochloride

Name: ACDPP hydrochloride
Brand: Tocris Bioscience
SKU: 2254

Tocris Bioscience, part of Bio-Techne | Catalog # 2254

COA / SDS

Selective mGlu5 antagonist

Discontinued Product

2254 has been discontinued. View all Group I mGluR Antagonists products.

Key Product Details

Description:	Selective mGlu₅ antagonist
Chemical Name:	3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	329.19

View Full Technical Details for ACDPP hydrochloride

Technical Data
Citations

Biological Activity for ACDPP hydrochloride

Antagonist at the mGlu₅ receptor (K_i = 295 nM). Inhibits human mGlu₅ receptor-mediated calcium flux with an IC₅₀ of 134 nM.

Technical Data for ACDPP hydrochloride

M. Wt	329.19
Formula	C₁₂H₁₃ClN₆O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
PubChem ID	16759168
InChi Key	CXIHLPLRTFPHKX-UHFFFAOYSA-N
Smiles	Cl.CN(C)C1=C(Cl)N=C(C(=O)NC2=CN=CC=C2)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ACDPP hydrochloride

References are publications that support the biological activity of the product.

Wang Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 2008 PMID: 18434517
Bonnefous Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 2005 PMID: 15686941

ACDPP hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2254

Key Product Details

Biological Activity for ACDPP hydrochloride

Technical Data for ACDPP hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ACDPP hydrochloride

Product Documents for ACDPP hydrochloride

COA

Certificate of Analysis

SDS

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